Patients w/ liver or kidney problems; high BP, heart disease, blood vessel disease eg, Raynaud's phenomenon, diabetes, overactive thyroid, angle closure glaucoma, pheochromocytoma, prostate problems; severe infection. Contains caffeine; avoid excessive caffeine-containing drinks. May cause dizziness; do not drive or operate machinery if affected. Do not take w/ other analgesics, antipyretics or cold relief medicine. Lactation. Not recommended for childn ≤12 yr.